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In vitro systems, while insightful, may not fully recapitulate the in vivo microenvironment

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thus, the levels of pyruvate carboxylase can greatly affect the sensitivity of tumor cells to inhibition of glutamine metabolism 111

Interestingly, in a study of drug nave first episode manic patients ( n = 56), serum ferritin was positively correlated with the BPRS (Brief Psychiatric Rating Scale) and YMRS (Young Mania Rating Scale) scores and patients showed higher inflammatory indices compared to their matched controls [127]